Publications

Relevant Consortium Publications

Collaborative within our Consortium:

  1. Kovacic JC, Dimmeler S, Harvey RP, Finkel T, Aikawa E, Krenning G and Baker A. Endothelial to Mesenchymal Transition in Cardiovascular Disease. J Am Coll Cardiol. 2019;73:190-209.
  2. Kovacic JC, Harvey RP and Dimmeler S. Cardiovascular regenerative medicine: digging in for the long haul. Cell Stem Cell. 2007;1:628-33.
  3. Santini MP, Forte E, Harvey RP and Kovacic JC. Developmental origin and lineage plasticity of endogenous cardiac stem cells. Development. 2016;143:1242-58.
  4. Kovacic JC, Muller DW, Harvey R and Graham RM. Update on the use of stem cells for cardiac disease. Intern Med J. 2005;35:348-56.

 

Aikawa

  1. Bartko PE, Dal-Bianco JP, Guerrero JL, Beaudoin J, Szymanski C, Kim DH, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Titus JS, Wylie-Sears J, Irvin WS, Messas E, Hagege AA, Carpentier A, Aikawa E, Bischoff J, Levine RA and Leducq Transatlantic Mitral N. Effect of Losartan on Mitral Valve Changes After Myocardial Infarction. J Am Coll Cardiol. 2017;70:1232-1244.
  2. Hjortnaes J, Shapero K, Goettsch C, Hutcheson JD, Keegan J, Kluin J, Mayer JE, Bischoff J and Aikawa E. Valvular interstitial cells suppress calcification of valvular endothelial cells. Atherosclerosis. 2015;242:251-260.
  3. Balachandran K, Alford PW, Wylie-Sears J, Goss JA, Grosberg A, Bischoff J, Aikawa E, Levine RA and Parker KK. Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve. Proc Natl Acad Sci U S A. 2011;108:19943-8.
  4. Bischoff J, Casanovas G, Wylie-Sears J, Kim DH, Bartko PE, Guerrero JL, Dal-Bianco JP, Beaudoin J, Garcia ML, Sullivan SM, Seybolt MM, Morris BA, Keegan J, Irvin WS, Aikawa E and Levine RA. CD45 Expression in Mitral Valve Endothelial Cells After Myocardial Infarction. Circ Res. 2016;119:1215-1225.
  5. Schlotter F, Halu A, Goto S, Blaser MC, Body SC, Lee LH, Higashi H, DeLaughter DM, Hutcheson JD, Vyas P, Pham T, Rogers MA, Sharma A, Seidman CE, Loscalzo J, Seidman JG, Aikawa M, Singh SA and Aikawa E. Spatiotemporal Multi-omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease. Circulation. 2018;138:377-93.
  6. Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G, Quillard T, Libby P, Aikawa M, Weinbaum S and Aikawa E. Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques. Nat Mater. 2016;15:335-43.
  7. van der Valk DC, van der Ven CFT, Blaser MC, Grolman JM, Wu PJ, Fenton OS, Lee LH, Tibbitt MW, Andresen JL, Wen JR, Ha AH, Buffolo F, van Mil A, Bouten CVC, Body SC, Mooney DJ, Sluijter JPG, Aikawa M, Hjortnaes J, Langer R and Aikawa E. Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics. Nanomaterials (Basel). 2018;8.

 

Baker

  1. Caruso P, Dempsie Y, Stevens HC, McDonald RA, Long L, Lu R, White K, Mair KM, McClure JD, Southwood M, Upton P, Xin M, van Rooij E, Olson EN, Morrell NW, MacLean MR and Baker AH. A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples. Circ Res. 2012;111:290-300.
  2. Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA and Aikawa E. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest. 2016;126:1323-36.

 

del Monte-Nieto

  1. Del Monte-Nieto G, Ramialison M, Adam AAS, Wu B, Aharonov A, D'Uva G, Bourke LM, Pitulescu ME, Chen H, de la Pompa JL, Shou W, Adams RH, Harten SK, Tzahor E, Zhou B and Harvey RP. Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation. Nature. 2018;557:439-445.

 

Dimmeler

  1. Manavski Y, Abel T, Hu J, Kleinlutzum D, Buchholz CJ, Belz C, Augustin HG, Boon RA and Dimmeler S. Endothelial transcription factor KLF2 negatively regulates liver regeneration via induction of activin A. Proc Natl Acad Sci U S A. 2017;114:3993-3998.
  2. Stellos K, Gatsiou A, Stamatelopoulos K, Perisic Matic L, John D, Lunella FF, Jae N, Rossbach O, Amrhein C, Sigala F, Boon RA, Furtig B, Manavski Y, You X, Uchida S, Keller T, Boeckel JN, Franco-Cereceda A, Maegdefessel L, Chen W, Schwalbe H, Bindereif A, Eriksson P, Hedin U, Zeiher AM and Dimmeler S. Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation. Nat Med. 2016;22:1140-1150.
  3. Wagner JUG, Chavakis E, Rogg EM, Muhly-Reinholz M, Glaser SF, Gunther S, John D, Bonini F, Zeiher AM, Schaefer L, Hannocks MJ, Boon RA and Dimmeler S. Switch in Laminin beta2 to Laminin beta1 Isoforms During Aging Controls Endothelial Cell Functions-Brief Report. Arterioscler Thromb Vasc Biol. 2018;38:1170-1177.
  4. Manavski Y, Lucas T, Glaser SF, Dorsheimer L, Gunther S, Braun T, Rieger MA, Zeiher AM, Boon RA and Dimmeler S. Clonal Expansion of Endothelial Cells Contributes to Ischemia-Induced Neovascularization. Circ Res. 2018;122:670-677.
  5. Neumann P, Jae N, Knau A, Glaser SF, Fouani Y, Rossbach O, Kruger M, John D, Bindereif A, Grote P, Boon RA and Dimmeler S. The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2. Nature communications. 2018;9:237.

 

Finkel

  1. Xiong J, Kawagishi H, Yan Y, Liu J, Wells QS, Edmunds LR, Fergusson MM, Yu ZX, Rovira, II, Brittain EL, Wolfgang MJ, Jurczak MJ, Fessel JP and Finkel T. A Metabolic Basis for Endothelial-to-Mesenchymal Transition. Molecular cell. 2018;69:689-698 e7.
  2. Singh KK, Lovren F, Pan Y, Quan A, Ramadan A, Matkar PN, Ehsan M, Sandhu P, Mantella LE, Gupta N, Teoh H, Parotto M, Tabuchi A, Kuebler WM, Al-Omran M, Finkel T and Verma S. The essential autophagy gene ATG7 modulates organ fibrosis via regulation of endothelial-to-mesenchymal transition. J Biol Chem. 2015;290:2547-59.
  3. Nomura M, Liu J, Rovira, II, Gonzalez-Hurtado E, Lee J, Wolfgang MJ and Finkel T. Fatty acid oxidation in macrophage polarization. Nat Immunol. 2016;17:216-7.
  4. Hill JM, Zalos G,Halcox JPJ, Schenke WH, Walclawiw MA, Quyyumi AA, Finkel T. Circulating Endothelial Progenitor Cells, Vascular Function, and Cardiovascular Risk. New England J. Med. 2003;348:593-600.
  5. Torisu T, Torisu K, Lee IH, Liu J, Malide D, Combs CA, Komatsu M, Cao L, Finkel T. Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor. Nature Medicine, 2013; 19:1281-1287. 

 

Gomez

  1. Gomez D, Shankman LS, Nguyen AT and Owens GK. Detection of histone modifications at specific gene loci in single cells in histological sections. Nature methods. 2013;10:171-7.
  2. Cherepanova OA, Gomez D, Shankman LS, Swiatlowska P, Williams J, Sarmento OF, Alencar GF, Hess DL, Bevard MH, Greene ES, Murgai M, Turner SD, Geng YJ, Bekiranov S, Connelly JJ, Tomilin A and Owens GK. Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective. Nat Med. 2016;22:657-65.
  3. Shankman LS, Gomez D, Cherepanova OA, Salmon M, Alencar GF, Haskins RM, Swiatlowska P, Newman AA, Greene ES, Straub AC, Isakson B, Randolph GJ and Owens GK. KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Nat Med. 2015;21:628-37.

 

Harvey

  1. Del Monte-Nieto G, Ramialison M, Adam AAS, Wu B, Aharonov A, D'Uva G, Bourke LM, Pitulescu ME, Chen H, de la Pompa JL, Shou W, Adams RH, Harten SK, Tzahor E, Zhou B and Harvey RP. Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation. Nature. 2018;557:439-445.
  2. Zamir L, Singh R, Nathan E, Patrick R, Yifa O, Yahalom-Ronen Y, Arraf AA, Schultheiss TM, Suo S, Han JJ, Peng G, Jing N, Wang Y, Palpant N, Tam PP, Harvey RP and Tzahor E. Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta. Elife. 2017;6.

 

Kovacic

  1. Kovacic JC, Mercader N, Torres M, Boehm M and Fuster V. Epithelial-to-mesenchymal and endothelial-to-mesenchymal transition: from cardiovascular development to disease. Circulation. 2012;125:1795-808.
  2. Evrard SM, Lecce L, Michelis KC, Nomura-Kitabayashi A, Pandey G, Purushothaman KR, d'Escamard V, Li JR, Hadri L, Fujitani K, Moreno PR, Benard L, Rimmele P, Cohain A, Mecham B, Randolph GJ, Nabel EG, Hajjar R, Fuster V, Boehm M and Kovacic JC. Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability. Nature communications. 2016;7:11853.
  3. Cooley BC, Nevado J, Mellad J, Yang D, St Hilaire C, Negro A, Fang F, Chen G, San H, Walts AD, Schwartzbeck RL, Taylor B, Lanzer JD, Wragg A, Elagha A, Beltran LE, Berry C, Feil R, Virmani R, Ladich E, Kovacic JC and Boehm M. TGF-beta signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling. Science translational medicine. 2014;6:227ra34.
  4. Jeong D, Lee MA, Li Y, Yang DK, Kho C, Oh JG, Hong G, Lee A, Song MH, LaRocca TJ, Chen J, Liang L, Mitsuyama S, D'Escamard V, Kovacic JC, Kwak TH, Hajjar RJ and Park WJ. Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis. J Am Coll Cardiol. 2016;67:1556-68.
  5. Michelis KC, Nomura-Kitabayashi A, Lecce L, Franzen O, Koplev S, Xu Y, Santini MP, D'Escamard V, Lee JTL, Fuster V, Hajjar R, Reddy RC, Chikwe J, Stelzer P, Filsoufi F, Stewart A, Anyanwu A, Bjorkegren JLM and Kovacic JC. CD90 Identifies Adventitial Mesenchymal Progenitor Cells in Adult Human Medium- and Large-Sized Arteries. Stem cell reports. 2018;11:242-257.
  6. Kovacic JC. The Endothelial-Metabolic Axis: A Novel Cardiometabolic Disease Target. Trends Endocrinol Metab. 2018;29:527-529.

 

Krenning

  1. Hajmousa G, Vogelaar P, Brouwer LA, van der Graaf AC, Henning RH and Krenning G. The 6-chromanol derivate SUL-109 enables prolonged hypothermic storage of adipose tissue-derived stem cells. Biomaterials. 2017;119:43-52.
  2. Moonen JR, Krenning G, Brinker MG, Koerts JA, van Luyn MJ and Harmsen MC. Endothelial progenitor cells give rise to pro-angiogenic smooth muscle-like progeny. Cardiovasc Res. 2010;86:506-15.
  3. Maleszewska M, Moonen JR, Huijkman N, van de Sluis B, Krenning G and Harmsen MC. IL-1beta and TGFbeta2 synergistically induce endothelial to mesenchymal transition in an NFkappaB-dependent manner. Immunobiology. 2013;218:443-54.
  4. Moonen JR, Lee ES, Schmidt M, Maleszewska M, Koerts JA, Brouwer LA, van Kooten TG, van Luyn MJ, Zeebregts CJ, Krenning G and Harmsen MC. Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress. Cardiovasc Res. 2015;108:377-86.
  5. Correia AC, Moonen JR, Brinker MG and Krenning G. FGF2 inhibits endothelial-mesenchymal transition through microRNA-20a-mediated repression of canonical TGF-beta signaling. J Cell Sci. 2016;129:569-79.
  6. Maleszewska M, Gjaltema RA, Krenning G and Harmsen MC. Enhancer of zeste homolog-2 (EZH2) methyltransferase regulates transgelin/smooth muscle-22alpha expression in endothelial cells in response to interleukin-1beta and transforming growth factor-beta2. Cell Signal. 2015;27:1589-96.
  7. Krenning G, Moonen JR, van Luyn MJ and Harmsen MC. Vascular smooth muscle cells for use in vascular tissue engineering obtained by endothelial-to-mesenchymal transdifferentiation (EnMT) on collagen matrices. Biomaterials. 2008;29:3703-11.
  8. Vanchin B, Offringa E, Friedrich J, Brinker MG, Kiers B, Pereira AC, Harmsen MC, Moonen JA and Krenning G. MicroRNA-374b induces endothelial-to-mesenchymal transition and early lesion formation through the inhibition of MAPK7 signaling. J Pathol. 2018; doi: 10.1002/path.5204

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