Prediction of Recurrent Events with 18F-Fluoride to Identify Ruptured and High-risk Coronary Artery Plaques in Patients with Myocardial Infarction

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Research Methods and Objectives

The investigators intend to recruit 700 patients hospitalised with myocardial infarction and proven multivessel coronary artery disease. All patients will undergo a combined CT coronary angiogram (CTCA) and PET scan using 18F-NaF as a tracer. Patients will then have clinical follow-up before undergoing a repeat CTCA at 2 years to assess progression of coronary disease. Clinical review of all patients will continue until study completion (given 2 years of recruitment this is likely to last 4 years) and following this the investigators will continue to monitor for further cardiovascular events via review of patient electronic health records for a further 5 years. The primary endpoint of the trial is to determine the prognostic significance of coronary 18F-NaF uptake. It is being undertaken in 8 centres in the UK as well as centres in Australia, Singapore and the United States of America.

Invasive Coronary Angiography

Underlying Theoretical Considerations

Principal Investigator, Co-Investigators, Other researcher

Chief Investigator: David Newby

Co-Investigators: Marc Dweck, Nick Mills

Key Publications

1. Joshi NV, Vesey AT, Williams MC, Shah ASV, Calvert PA, Craighead FHM, Yeoh SE, Wallace W, Salter D, Fletcher AM, van Beek EJR, Flapan AD, Uren NG, Behan MWH, Cruden NLM, Mills NL, Fox KAA, Rudd JHF, Dweck MR*, Newby DE*. 18F-Fluoride positron emission tomography identifies ruptured and high-risk coronary atherosclerotic plaques. Lancet 2014;383:705-713.
2. Irkle A, Vesey AT, Lewis DY, Sicrocalcification by ¹⁸F-sodium fluoride positron emission tomography. Nat Commun. 2015;6:7495.