Understanding the Pathogenesis of Type 1 Diabetes

Using mouse models to study the development of Diabetes

Research Methods and Objectives

Using human islets transplanted into immunodeficient mice under different glycaemic conditions, we aim to study the secretion of hormones from human islets with high resolution microscopy.

Cells within islet visualised using HiVolution
Cells within islet visualised using HiVolution: super resolution live imaging with confocal microscope (Leica SP8 3D multi-colour gSTED). Cells stained with mitotracker green (490/516). Image - Professor Rory Duncan’s laboratory, Heriot Watt University by Medical Research Scotland funded PhD student Dr Garcia Burgos.

Principal Investigator, Co-Investigators, Other researchers

Principal Investigators: Rory McCrimmon - University of Dundee, Rory Duncan - Heriot Watt University and Shareen Forbes - University of Edinburgh

Collaborators: Scottish National Blood Transfusion Service, Helmsley Foundation, nPOD

Team members involved in this programme: Gary BorthwickAdrian Garcia Burgos, Alison McNeilly, Paul BorgoyneJune Noble


Helmsley Foundation