The primary aim of our research is to characterise the molecular mechanisms through which resident cardiac endothelial cells contribute to vascular regeneration in the post-ischaemic heart. Image Our research is centred upon identifying the genetic targets and pathways through which the cells that line the blood vessels of the heart (endothelial cells) can contribute to repair of the heart muscle wall following a heart attack (myocardial infarction). We aim to develop strategies to enhance cardiovascular repair and regeneration through manipulation of these targets. Research Methods and Objectives Use of endothelial cell-specific multispectral transgenic mouse models (Confetti mice) for lineage analysis of vascular turnover and regeneration In vivo models of myocardial infarction to study cardiovascular regeneration Advanced imaging and analysis Single cell RNA-Sequencing and bioinformatics Human endothelial cell isolation and primary culture (BOEC, vessel wall EC) Principal Investigator, Co-Investigators, Other researchers Dr Mairi Brittan (PI) Dr Cass Li (Postdoc) Mr Manolis Solomonidis (PhD student) This article was published on 2024-03-19
